Neuroimmune interactions
Neuroimmune interactions refer to the dynamic and bidirectional communication between the nervous and immune systems. These interactions play a crucial role in maintaining homeostasis, responding to injury or infection, and influencing behavior and mental health. Dysregulation of neuroimmune signaling is implicated in a wide range of neurological, psychiatric, and systemic diseases.
Key Components of Neuroimmune Interactions:
Immune Cells in the Central Nervous System (CNS)
Although the CNS is considered an "immune-privileged" site, various immune cells are active in maintaining brain health:
- Microglia:
- Resident immune cells of the CNS.
- Regulate synaptic pruning, inflammation, and phagocytosis.
- Astrocytes:
- Release cytokines, chemokines, and growth factors to mediate neuroimmune responses.
- Peripheral Immune Cells:
- T cells, B cells, and macrophages can infiltrate the CNS in pathological conditions (e.g., multiple sclerosis, neuroinfections).
- Endothelial Cells:
- Part of the blood-brain barrier (BBB), they regulate immune cell trafficking into the CNS
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