Neuroinflammation

 The central nervous system (CNS) can become inflamed due to autoimmune diseases, toxicity, injury, or infection. As the specific resident macrophage cells in the central nervous system, microglia are essential for the development and treatment of neuroinflammation. Their effect on neurones is complicated, though. The local brain microenvironment has a direct impact on the phenotypic plasticity of microglia. Therefore, the underlying variety of the microglial population is not adequately reflected by the M1/M2 dichotomy labelling that is used to describe other macrophage activity. It is well known that the expression of genes included in both M1 and M2 profiles is a component of the "disease-associated microglia signature" that microglia may exhibit in neurodegenerative diseases. Microglia thus have a role in the neuronal loss typical of these disorders, even though they are crucial for the first response to neuronal injury.

 

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