32^nd European Neurology Congress

Inderjit Singh is a University Professor at the Medical University of South Carolina, USA. He is investigating the mechanisms of stroke and other neuroinflammatory diseases including vascular dementia associated with Alzheimer’s disease. Over the years, he has authored more than 300 high quality peer reviewed original articles and book chapters. He is continuously funded by the NIH for his studies on the disease mechanisms of neurodegeneration. Based on his credentials in neurodegenerative studies; he was awarded Jacob Javits Award for meritorious research in neurological sciences by NINDS/NIH (2002-2009). One of the goals is to evaluate a stroke drug therapy using clinically relevant stroke mouse models of cerebral ischemia and reperfusion (IR) and permanent ischemia (IS). The focus of the present study is on functional recovery and the mechanisms regulated by S-nitrosylation of HIF-1α using an effi cient S-nitrosylating agent S-nitrosglutathione (GSNO). GSNO is a natural component of the human body and its exogenous administration in human studies is not associated with adverse effects. In neuroinflammatory diseases, the levels of S-nitrosylation are decreased due to increased formation of peroxynitrite from NO and superoxide thus S-nitrosylation-mediated cellular functions are dysregulated. Presently, we are investigating neuroprotection/neuro-recovery therapy using GSNO in stroke, TBI and SCI.