34^th European Neurology Congress

Biography

Biography: Yuri Danilov

Abstract

Statement of the Problem: Cerebral Palsy (CP) is a neuro -developmental disorder characterized by abnormalities of muscle tone, movement, and motor skills, and is attributed to injury to the developing brain. Patients often present with a mixed movement disorder comprising dystonia and choreoathetosis, axial hypotonia, and sometimes coexisting spasticity leading to severe impairment in activities of daily living. The majority of CP symptoms are considered unpreventable and incurable. The combination of Translingual Neurostimulation (TLNS) and contemporary physical therapy methods demonstrate high effectiveness in balance and movement skills rehabilitation. 

Methodology & Theoretical Orientation: The study includes 172 children (112 in the primary active and 60 in control groups), age 2-16 years old. The therapy course consists of two weeks of physical therapy combined with 20 min stimulation sessions twice a day (physical therapy only for the control group). Several subjects’ subgroups got up to 5 subsequent therapy sessions with 6-12 months apart. The balance performance was evaluated by the Berg test. Motor skills were evaluated by GMFCS and FMS scales and hands and legs plasticity by the Ashworth scale.

Findings: In the control group, physical therapy was minimally effective (in 77%of subjects) and did not sustain in between courses. In the active group, the balance performance improved much stronger in 92%of subjects and about twice better than in the control group. Improved balance sustained in between courses and accumulated sequentially. As a final cumulative result, the balance improved up to 30-35 points on the Berg scale. Similar results were observed in the improvement of motor skills development and decrease of plasticity.

Conclusion & Significance: Translingual neurostimulation, in combination with physical therapy, is a useful tool to facilitate rehabilitation in cerebral palsy kids. Achieved balance improvement sustains up to 12 months in between sessions and can be progressively accumulated in sequential therapy courses.

Recent Publications:

1.Wildenberg, J.C., Tyler, M.E., Danilov, Y.P., Kaczmarek, K.A., Meyerand, M.E. (2010) Sustained cortical and subcortical neuromodulation induced by electrical tongue stimulation. Brain Imaging and Behavior, 4, 199-210.

2.Harbourne, R., Becker, K., Arpin, D. J., Wilson, T. W., & Kurz, M. J. (2014). Improving the motor skill of children with posterior fossa syndrome: a case series. Pediatric Physical Therapy, 26(4), 462-468.

3.Danilov, Y., K. Kaczmarek, K. Skinner and M. Tyler (2015). Cranial nerve noninvasive neuromodulation: New approach to neurorehabilitation. Chapter 44. In: Brain neurotrauma: Molecular, neuropsychological, and rehabilitation aspects. F. H. Kobeissy and S. W. Hoffman, CRC Press: 603-628

4.Ignatova, Т.S., Scoromets, А.P., Kolbin, V.Е.,Sarana, А.М., Sherbak, S.G., Makarenko, S.V. , Deineko, V.V., Danilov, Y.P. (2016) Translingual Brain Neurostimulation In Treatment Of The Pediatric Cerebral Palsy. Journal of restorative medicine and rehabilitation, 6, pp.10-16.

5.Danilov, Y., & Paltin, D. (2018). Translingual Neurostimulation (TLNS): Perspective on a Novel Approach to Neurorehabilitation after Brain Injury. In Pre-Clinical and Clinical Methods in Brain Trauma Research, Chapter 19, (pp. 307-327). Humana Press, New York, NY.