Sandeep
Jawaharlal Nehru University, India
Title: Apocynin administration ameliorates motor deficits in Paraquat-induced Parkinsonism
Biography
Biography: Sandeep
Abstract
Background: Parkinson's disease (PD) is the second most common progressive neurological disorder after alzheimer’s, characterized by presence of intra- cytoplasmic inclusion bodies known as lewy body containing α- synuclein aggregate and the loss of dopaminergic neurons in the substantia nigra regions of the brain. The exact cause of dopaminergic neuronal loss in PD remains unknown for a long time, however, recent studies report that oxidative stress plays a key role in the pathogenesis of PD. Paraquat (PQ), a widely used herbicide is an oxidative stress inducer that has been implicated as a potential risk factor for the development of PD. Pharmacological approaches targeting antioxidant machinery may have therapeutic value against PD. Flavonoids are naturally occurring polyphenolic compounds that display a variety of therapeutic properties against oxidative stress. Apocynin (4-hydroxy-3- methoxyacetophenone) is a natural flavonoid obtained from medicinal plant Picrorhiza kurroa that exhibits neuroprotection against PD-related pathology. However, studies on its neuroprotective role and the underlying mechanisms are scarce.
Aim: The proposed study will explore the potential beneficial effect of Apocynin on PQ-induced motor deficits in rat model of Parkinsonism.
Methods: As a part of preliminary study, we have developed PQ-induced Parkinsonism model in adult Wistar rats. We performed motor coordination related behavioral experiments and histopathological studies in order to validate the establishment of PQ-induced Parkinsonism. Then we determined the effect of apocynin on PQ-induced motor deficits in rat model of Parkinsonism.
Results: PQ-induced nigro-striatal dopaminergic neurodegenerations in the rat model of Parkinsonism. Apocynin improved motor deficits in PQ-induced rat model of Parkinsonism.
Conclusion: Apocynin treatment ameliorates PQ-induced motor deficits in the rat model of Parkinsonism. In future, we will be assessing the neuroprotective effect of Apocynin in the developed model of Parkinsonism.
Keywords: Parkinson’s disease, Paraquat, Neuroprotection, Apocynin, Neurodegeneration.