Noboru Imai
Japanese Red Cross Shizuoka Hospital, Japan
Title: Dynamic resting state functional connectivity differences between ictal and the pre or postictal phase of migraine
Biography
Biography: Noboru Imai
Abstract
Background and Aims: Migraine is a phasic disease, with ictal, preictal and postictal phases. Aberrant static restingstate functional connectivity (rs-FC) has been demonstrated in migraine sufferers. However, there are few studies on dynamic rs-FC during migraine. This study aimed to investigate the differences of static and dynamic rs-FC between ictal and pre- or postictal phases of migraine.
Methods: Migraineurs in the ictal (n=16), preictal (11) and postictal (10) phases underwent 3T MRI. We compared the static and dynamic rs-FC among subjects in the ictal preictal and postictal phases using region-of-interest to region-of-interest analyses of 91 cortical, 17 subcortical and 30 infratentorial areas.
Results: Analysis of static rs-FC showed no significant differences among migraineurs in the ictal, preictal and postictal phases. Analysis of dynamic rs-FC demonstrated that migraineurs in the ictal phase had significantly less connectivity between right thalamus and right insular cortex, between left PAG and right interior frontal gyrus, and six other region-of-interest pairs than migraineurs in the preictal phase (Figure 1), as well as significantly less connectivity between the left thalamus and left cerebellum and six other region-of-interest pairs than migraineurs in the postictal phase.
Conclusions: In our study, dynamic rs-FC analysis revealed significantly different connectivity pairs between migraineurs in the ictal and pre- or postictal phases. Our study also revealed that the migraine brain dynamically
changed rs-FC during the preictal, ictal and postictal phases.
Recent Publications:
• Dumkrieger G, Chong C D, Ross K, et al. (2019) Static and dynamic functional connectivity differences between migraine and persistent post-traumatic headache: A resting-state magnetic resonance imaging study. Cephalalgia 39(11):1366-1381.
•Lee M J, Park B Y, Cho S, et al. (2019) Dynamic functional connectivity of migraine brain: a resting-state fMRI study. Pain 160(12):2776-2786.
• Tu Y, Fu Z, Zeng F, et al. (2019) Abnormal thalamocortical network dynamics in migraine. Neurology 92(23):e2706-e2716.
• Coppola G, Di Renzo A, Petolicchio B, et al. (2019) Aberrant interactions of cortical networks in chronic migraine: A resting-state fMRI study. Neurology 92(22):e2550-e2558.
• May A and Burstein R (2019) Hypothalamic regulation of headache and migraine. Cephalalgia. 39(13):1710-1719.
