Biography
Biography: Umur Kayabasi
Abstract
Introduction: Tau protein plays a crucial role in many neurodegenerative diseases including Alzheimer's disease (AD). Tau inclusions and amyloid beta (AB) depositions have been described in the post-mortem retina exams of AD patients. Cryo- electron microscopy (Cryo- EM) was recently used to detect the detailed structure of Tau filaments.
Methods & Results: We examined the retinas of PET-proven live AD patients by spectral domain optical scanning tomography (SD- OCT) and fundus auto fluoresce in (FAF). The hyper or hypo-fluorescent lesions in the retina were scanned by OCT and images that completely corresponded with the histopathological and Cryo-EM shapes of tau filaments were observed.
Conclusion: Retinal tau is a very promising target to detect early changes in AD and retinal imaging may be an exciting and trustable technique to predict and monitor the disease.