Mawadda Karrar Ibrahim
University of Bahri, Sudan
Title: Possible predisposing factors for thrombotic cerebrovasculer accidents in Sudanese patients
Biography
Biography: Mawadda Karrar Ibrahim
Abstract
Background: Stroke is a condition that involves loss of brain functions caused by loss of blood supply to part of the brain. It is the third most common cause of death in the developed countries and in 40% of young patients no cause can be identified.
Methodology: A case control study involving 100 patients with thrombotic CVA and 300 age and gender matched healthy control (2002-2004).
Results: In this study, the hematological profiles for patients were within normal range. With normal ranges of APTT (activated partial thromboplastin time) and thrombin clotting time, LA and dysfibrinogenemias can be excluded. Natural anticoagulants (PC, PS, and AT-III) were at the lower range of normal in all patients (p=0.04), and were significantly lower from those of the age (p=0.04), and gender matched controls (p=0.02). In addition, most of the female patients were on oral contraceptive pills at the time of the stroke. Female patients had even lower AT-III levels compared to female controls.
Conclusion: Relative PC, PS, AT-111 deficiencies could be a possible cause of increase thromboembolic CVAs in Sudan.