Abdullah Elkeshy
Umm Al-Qura University, Saudi Arabia
Title: The Possible Role of the Endoneurial Fibroblast-like Cells in Resolution of the Endoneurial Edema Following Nerve Crush Injury
Biography
Biography: Abdullah Elkeshy
Abstract
Forty-two albino male rats aged between 30 and 40 days (weighted 200 g to 250 g) were used in the present study. The left sural nerves of 36 rats were subjected to crush injury at 1 to 6 weeks intervals using 6 animals at each interval. The right and left sural nerves of the rest 6 rats were used as a control. After 2 weeks of the crush injury, the endoneurium showed channel-like spaces that were lined by the collagen bundles with fibroblast-like cells processes. These channels contained degenerated myelin and were connected with the subperineurial spaces. Some of the flattened fibroblast-like cells were arranged in several layers in the subperineurial space, forming barrier-like cellular sheets localizing the endoneurial edema in these spaces. Fibroblast-like cells also wrapped the regenerating nerve fibers by their branching cytoplasmic processes. At the end of the third week, the flattened fibroblasts formed nearly continuous sheets in the subperineurial space. Macrophages were frequently noticed between these cellular barrier-like sheets and in the subperineurial and perivascular spaces. Conclusion: it could be concluded that the endoneurial fibroblast-like cells form barrier-like cellular sheets that localized the endoneurial edema in the subperineurial space and create also the endoneurial channel-like spaces containing degenerated myelin and endoneurial edema helping the resolution of such edema.