Davide Moretti
National Institute of Research and Cure for Mental disorders and Dementia, Italy
Title: EEG reveals lower regional blood perfusion and atrophy of temporo-parietal network associated to memory deficits and hippocampal volume reduction in mci due to alzheimer's disease
Biography
Biography: Davide Moretti
Abstract
The increase of EEG upper/low alpha power ratio has been associated to a lower regional blood perfusion, to atrophy of temporo-parietal brain areas, and to reduction of hippocampal volume in subjects affected by mild cognitive impairment (MCI) due to Alzheimer's disease as compared to non converters.Moreover, Also, The EEG theta frequency activity is quite different in the groups. We investigated the correlation between the biomarkers and memory performances.Methods: EEG Alpha3/alpha2 power ratio as well as cortical thickness was computed for each subject has been computed in 74 adult subjects with prodromal AD. In 27 of them underwent also blood perfusion assessment sby ingle-photon emission computed tomography (SPECT) Pearson’s r was used to assess the topography of the correlation between cortical thinning as well as between brain perfusion and memory impairment Results: In higher alpha3/alpha2 frequency power ratio group greater cortical atrophy and lower regional perfusional value in temporo-parietal cortex was found correlated to an increase of EEG theta frequency. Moreover, both in MRI group and in the SPECT MCI group memory impairment was more pronounced Conclusion: High EEG upper/low alpha power ratio was associated with cortical thinning lower perfusion in temporo-parietal. Moreover, atrophy and lower regional perfusional rate were both significantly correlated with emory impairment in MCI subjects. The of EEG upper/low alpha frequency power ratio could be useful for identifying individuals at risk for progression to AD dementia and may be of value in clinical context.