Gulsel Yurtdas Kırımlıoglu
Anadolu University, Turkey.
Title: Release characteristics of gaba loaded halloysite nanotube system: investigation on the seizure parameters in epileptic rats
Biography
Biography: Gulsel Yurtdas Kırımlıoglu
Abstract
Gamma aminobutyric acid (GABA), serves as the major inhibitory neurotransmitter, has a central role in neural control. Inhibition of GABA synthesis, blockage of release or postsynaptic reaction were determined to provoke convulsions. Significant reductions in brain GABA concentration were seen in patients with different epileptic syndromes. Several new approaches are being developed in an attempt to increase the entry and persistence of antiepileptic agents in the brain. One of the main strategy is nanosized drug delivery systems for the treatment of epilepsy. Halloysite nanotubes (HNT) is natural aluminosilicate clay with hollow tubular structure which allows loading drugs inside nanotubes lumens. In this study, GABA was successfully incorporated into HNT depending on the most recent epilepsy theory related to GABA. Characterization, drug loading, in vitro release studies and cytotoxicity test were performed on HNTs. Anticonvulsant effect of drug loaded HNT system were evaluated using pentylenetetrazole induced epileptic rats for in vivo studies. The latency to myoclonic jerks and incidence of generalized tonic clonic seizures with loss of righting reflex were noted as seizure parameters.
