Biography
Biography: Alessandro Morelli
Abstract
A new paradigm other than insulator may arise for myelin, consistent to the fact that myelination is not continuous, as previously thought, and that myelin can aerobically synthesize ATP and deliver it to the axoplasm trough gap-junctions. Myelination is triggered by neuronal activity, which in turn regulates myelin remodeling. It may be hypothesized that after birth, intense firing depletes axonal ATP causing a rise in Adenosine, that triggers myelination (through purinergic receptor signalling): only those neurons which are fed with ATP can survive. Anoxia causes memory loss: i.e. memory requires energy. It may represent a neural network energized by myelination.
